Oxyhemoglobin Dissociation Curve
Left Shift - decreased unloading of O2 at tissue level (i.e. increased affinity)
- decr H+ (alkalosis)
- decr temperature
- 2 , 3 -diphosphoglycerate:
• stored red blood cells
- Hb variant
• fetal hæmoglobin
• methæmoglobin
• carboxyhæmoglobin
- Carbon monoxide poisoning
- Hypophosphatæmia
Right Shift - increased unloading of O2 at tissue level (i.e. decreased affinity)
- incr H+ (acidosis)
- incr temperature
- incr 2,3-diphosphoglycerate:
• pregnancy
• chronic anæmia
• arterial hypoxemia
- Sickle cell anemia
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