TOPCAT - Spironolactone for Heart Failure with Preserved Ejection Fraction N Engl J Med 2014; 370:1383-1392 https://www.nejm.org/doi/10.1056/NE CONCLUSIONS: In patients with heart failure and a preserved ejection fraction, treatment with spironolactone did not significantly reduce the incidence of the primary composite outcome of death from cardiovascular causes, aborted cardiac arrest, or hospitalization for the management of heart failure. - Visual Abstract by Usama Nasir MD @usamanasirmd #TOPCAT #Spironolactone #HFpEF #dCHF #Cardiology #EBM #VisualAbstract #Trial
