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diagnosis nephrology differential glomerulonephritis algorithm classification glomerular hematology microscopy renal acanthocyte chronic clinical cll comparison cryoglobulinemia disease diseases intrinsic leukemia
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... StanfordChiefs #RPGN
Intrinsic Renal Disease - Differential Diagnosis Vascular: • Macrovascular: Renal artery occlusion, Fibromuscular disease • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... Glomerulonephritis #RPGN
Acanthocyte on Urine Microscopy Not a spaceship, not a UFO, just an acanthocyte caught “flying” in dark
presentation of RPGN
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 Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
GN • Amyloid RPGN
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... , CFHR5 neph) MPGN ... Glomerulonephritis #MPGN
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Liver, kidney (MPGN
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
atypical HUS; MPGN
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• MPGN: Paraneoplastic
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