SPICE (SPACE) Organisms
Gram-negative bacteria that have inducible, chromosomal beta-lactamase genes known as AmpC - Resistance may not be detected on initial susceptibility testing, but can develop resistance while on therapy to all beta-lactams EXCEPT carbapenems (Cefepime and Piperacillin/Tazobactam can be used with caution as well)
Organisms in this group include:
• Serratia
• Providencia
• "Indole-positive" Proteus species / Acinetobacter
• Citrobacter
• Enterobacter species
Other organisms in this class include: Acinetobacter, Cronobacter, Edwardsiella, Hafnia, Morganella, and rarely Pseudomonas
#Diagnosis #Microbiology #SPICE #SPACE #Bacteria #Organisms #AmpC #Resistance #Antibiotics
