Major Segments of the Nephron and their Functions - Glomerulus - Formation of glomerular filtrate - Proximal convoluted tubule (PCT) - Reabsorption of 65% of filtered Na+/K+/CA2+, and Mg2+; 85% of NaHCO3, and nearly 100% of glucose and amino acids. Isosmotic reabsorption of water. - Proximal tubule, straight segments - Secretion and reabsorption of organic acids and bases, including uric acid and most diuretics - Thin descending limb of Henle's loop - Passive reabsorption of water - Thick ascending limb of Henle's loop (TAL) - Active reabsorption of 15-25% of filtered Na+/K+/Cl-,• secondary reabsorption of CA2+ and Mg2+ - Distal convoluted tubule (DCT) - Active reabsorption of 4—8% of filtered Na+ and Cl-; CA2+ reabsorption under parathyroid hormone control - Cortical collecting tubule (CCT) - Na+ reabsorption (2-5%) coupled to K+and H+ secretion - Medullary collecting duct - Water reabsorption under vasopressin control #Nephron #Segments #Function #Pathophysiology #Tubules #Table #Pharmacology
