Ipilimumab-Induced Hypophysitis. Pituitary gland enlargement occurs on therapy & resolves after therapy. - Ipilimumab is a monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, and adverse events may occur due increased T-cell activation. - Clinically, patients can develop anterior hypopituitarism. - On imaging, pituitary enlargement is the main finding, while stalk thickening can also be seen. - Resolves after therapy. - History of drug therapy important to not mistake for a metastasis. Dr. Mark Mamlouk @ https://twitter.com/MarkMamloukMD #Ipilimumab #DrugInduced #Hypophysitis #MRIBrain #Diagnosis #Clinical #Radiology
