Antifungal Organ System Tissue Penetration Concentrations in tissues and body fluids for each systemic antifungal agent relative to its concentration in plasma. X, human data; O, animal data. Colors illustrate differing ratios; multiple colors within a column give the range of published data. Red, from below level of detection to ≤0.5 times the plasma concentration; yellow, from >0.5 times to ≤5 times the plasma concentration; green, >5 times the plasma concentration; white, no data. ●, pleural fluid, buccal mucosa, or pancreatic pseudocyst; open diamond, based on autopsy data and human pharmacokinetics; Ω, wound fluid; o2, only detected in inflamed eyes; o3, bronchial secretions; x3, below level of detection in bronchial secretions; o4, pulmonary lymph; x5, bronchial biopsy specimen. #Antifungal #OrganSystem #Tissue #Penetration #Concentrations #Pharmacology
