Biphasic Illness of Leptospirosis Some patients do not progress to severe disease. Others, rapidly develop severe disease w/o brief interval symptom improvement. Septicemic phase (5-14 days): • Fever • Headache • Myalgia (esp. calf tenderness) • Conjunctival suffusion (redness w/o exudate) • Pretibial maculopapular rash • Others: nausea, vomiting, abdominal pain, diarrhea, cough Immune phase (4-30 days): • Aseptic meningitis • Weil's disease (renal + hepatic dysfunction) • Pulmonary hemorrhage • ARDS • Shock and multi-organ failure - WuidQ: Washington University ID Questions @WuidQ #Leptospirosis #Biphasic #Phases #Diagnosis #Illness #Signs
