Drugs for Depression and Anxiety Disorders Selective Serotonin Reuptake Inhibitors • Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone • Anxiety and depression disorders • Obsessive-compulsive disorder, PTSD • SERT selective; little effect on NET • Vilazodone also acts as 5HTIA partial agonist Serotonin-Norepinephrine Reuptake Inhibitors • Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran, Levomilnacipran • Anxiety and depression, ADHD, autism, fibromyalgia, PTSD, menopause symptoms • Inhibitors of SERT and NET Tricyclic Antidepressants Amitriptyline, Clomipramine, Doxepin, Imipramine, Trimipramine, Nortriptyline, Maprotiline, Protriptyline, Desipramine, Amoxapine • Block SERT, NET, a1, H1 and M1 receptors • Major depression Atypical Antipsychotics • Aripiprazole, Brexpiprazole, Lurasidone, Olanzapine, Quetiapine, Risperidone • Resistant major depression and psychotic disorders • Schizophrenia • Bipolar depression Monoamine Oxidase Inhibitors • Isocarboxazid, Phenelzine, Selegiline, Tranylcypromine • Inhibit MAOA and MAOB to prevent NE, DA, and 5HT breakdown • Major depression disorders resistant to other antidepressants Atypical Antidepressants • Bupropion, Trazodone, Nefazodone, Mirtazapine, Mianserin, Vortioxetine • Depression • Smoking cessation (bupropion) • Insomnia (low-dose trazodone) #Depression #Anxiety #Disorders #Medications #Table #Pharmacology #Management
