Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings
Predisposing Factors:
- Immunocompromised, Diabetes,
- Elderly, Female (short urethra)
- Stagnant urine (anatomical variant, obstruction, neurogenic bladder, urinary reflux, pregnancy)
- Indwelling urinary catheter, stent, nephrostomy tube
-> Impairment of body's usual defense system, stagnant urine, iatrogenic growth surfaces allow bacterial accumulation
Lower Urinary Tract Infection (LUTI) -> Bacteria ascend ureters from lower tract: As a complication of asymptomatic bacteriuria or cystitis (see LUTI slide) -> Bacteria's unique pili allow them to adhere to renal parenchyma -> Bacterial proliferation
Usual Pathogens ("KEEPS"):
K — Klebsiella
E — E. coli
E — Enterococcus, Enterobacteriaceae
P — Proteus, Pseudomonas
S — Staph. saprophyticus, Serratia
#Upper #UrinaryTractInfection #UUTI #Pathophysiology #Signs #Symptoms
