Bipolar Disorder: Pathogenesis and Clinical Findings • Disruption of emotional homeostasis • Oscillation between mood states - Individual variability in disease course Manic Episode - Minimum 1 week, or requiring hospitalization - elevated/expansive/irritable mood - Incr goal directed behaviours/agitation - Decr need for sleep - distractibility - racing thoughts - pressured speech - Incr euphoria - Incr grandiosity - Incr irritability - Incr risk taking Euthymic Mood - Definite periods of normal mood - Primary treatment goal is to maintain this state Depressive Episode - Minimum 2 weeks - depressed mood - Incr withdrawal - Incr guilt, anxiety - Incr hopelessness - Decr pleasure - Decr concentration - Change sleep, fatigue - Change weight, appetite - psychomotor agitation/retardation - Incr suicidal thoughts and behaviours #Bipolar #Disorder #MoodDisorders #Diagnosis #Pathophysiology #Signs #Symptoms #Psychiatry
