Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings Symptoms (included in DSM 5 criteria) - Present during same two week period and represent change from previous functioning: - Anhedonia (loss of interest/pleasure) - Anergia (fatigue) - Insomnia or hypersomnia - Feelings of worthlessness or excessive guilt - Poor cognition/concentration - Depressed Mood - Appetite or weight change (Incr or Decr) - Psychomotor agitation or retardation - Recurrent thoughts of death or suicide Other Symptoms: - Loss of libido - Mood varies by time of day (diurnal variation) - Worse in winter (Seasonal Affective Disorder) - Onset in month after delivery (MDD with post partum onset) - Anxiety - Hallucinations (MDD with psychotic features) - Delusions (MDD with psychotic features) #MDD #MajorDepressiveDisorder #Depression #MoodDisorders #Diagnosis #Pathophysiology #Signs #Symptoms #Psychiatry
