Alcohol Use Disorder: Pathogenesis and Clinical Findings • Tolerance (reduced sensitivity to effects of EtOH) • Social Impairment - Failure to fulfill role obligations (work, school, home) - Continued use despite social problems exacerbated by EtOH - Important social, occupational, recreational activities reduced • Risky Substance Use - Recurrent use of alcohol in hazardous situations - Continued use despite knowledge of consequences • Impaired Control - Incr in alcohol consumption - Unsuccessful attempts to reduce alcohol use - Incr in time spent pursuing / using / recovering from EtOH - Alcohol craving - Intense desire to use EtOH • Withdrawal symptoms - Sweating, tachycardia, nausea/vomiting, tremor, insomnia, seizure, and anxiety #AlcoholUseDisorder #EtOH #Pathophysiology #Diagnosis #Signs #Symptoms #Psychiatry