Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings Psychological Hypothesis • Cognitive behavioral model: Emotional disturbance arising from dysfunctional beliefs about situations or stimuli • Avoidance/Compulsions maintain maladaptive beliefs and anxiety Biological Hypotheses • Serotonin: Hypersensitivity of postsynaptic serotonin receptors -> Dysregulation of anxiety • Structural model: Dysfunction of brain circuits in the oribito-frontal-subcortical regions suspected Genetics • 27-47% heritability in twin studies -> Obsessive-Compulsive Disorder (OCD) Obsessions - Unwanted/intrusive thoughts, ideas, images, impulses that intrude into consciousness Compulsions - Urges to perform overt behavioural or mental rituals to reduce obsessional anxiety or distress about feared consequences #OCPD #ObsessiveCompulsive #PersonalityDisorder #Diagnosis #Psychiatry #Signs #Symptoms
