162 results
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Lysis Syndrome (TLS ... Abnormalities of TLS ... Laboratory TLS ... mg/dL Clinical TLS ... Treatment of TLS
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
lysis syndrome (TLS ... TumorLysis #syndrome #TLS
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Lysis Syndrome (TLS ... TumorLysis #Syndrome #TLS
Crystal cast in patient with AKI and TLS on Urine Microscopy

Randy Luciano MD, PhD @RandyLucianoMD

#TLS #Crystal
patient with AKI and TLS ... RandyLucianoMD #TLS
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Treatment of Clinical TLS ... MatthewHoMD #TLS
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Lysis Syndrome (TLS ... Lysis #Syndrome #TLS
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
#Presentation #TLS
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
leukapheresis - TLS ... Lysis #Syndrome #TLS
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
uric acid (rhabdo/TLS
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Lysis #Syndrome #TLS