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diagnosis nephrology differential algorithm causes glomerular glomerulonephritis nephrotic proteinuria syndrome champs classification clinical complement diseases electronmicroscopy gbm hematology hematuria hypocomplementemia
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative ... malignant HTN #Membranoproliferative
This image shows acellular scanning EM showing glomerular basement membrane duplication at high power in a
glomerulus with a membranoproliferative ... arkanalabs #GBM #membranoproliferative
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 Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Infection-Related, Membranoproliferative
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome: - Acute poststreptococcal glomerulonephritis - Rapidly progressive
glomerulonephritis - Membranoproliferative
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
atheroembolic, AIHA M - Membranoproliferative
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
nephropathy • Membranoproliferative
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
wall) • Membranoproliferative
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
atypical HUS; MPGN = membranoproliferative
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Glomerulonephritis: 5%-6% • Membranoproliferative
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