Paget's Disease of Bone • Characterized by an ↑ rate of bone turnover with both excessive resorption and formation of bone, leading to a "mosaic" lamellar bone pattern appearance on x-ray. • Caused by (suspected) the effects of a latent viral infection in genetically susceptible individuals. • Associated with 1° hyperparathyroidism and ↑ risk for osteosarcoma. • The disease can affect one (monostotic) or more (polystotic) bones, with the skull, vertebral bodies, pelvis, and long bones most commonly affected. By @medperspective #Pagets #Disease #Bone #diagnosis #management #treatment

Causes of clubbing By @medperspective #clubbing #differential #diagnosis #causes #fingernail #nails