Cephalosporin Coverage by Generation - HENPECKS Mnemonic 1st Gen: PEK (Proteus, E. coli, Klebsiella) 2nd Gen: HNPEK (Add Haemophilus, Neisseria) 3rd Gen: HENPECKS (Add Enterobacter, Citrobacter, Serratia) 3rd Gen Ceftazidime: HENPECKS + PsA + A (Add Pseudomonas and Acinetobacter; Lose Streptococcus and MSSA) 4th Gen Cefepime: HENPECKS + PSA + A (Add back Streptococcus and MSSA) 5th Gen Ceftaroline: HENPECKS (Add MRSA; Lose PSA + A) - Courtney Moc, PharmD, MS @CourtneyMoc #Cephalosporins #Coverage #antibiotics #pharmacology #Generations #HENPECKS #Mnemonic #spectrum