·
×
This browser does not support the video element.
No Source!
Private
Like
Bookmark
Share
facebook
linkedin
twitter
reddit
pinterest
email
Whatsapp
Related
×
GrepMed
Sign up
Login
about
browse
contact
Support GrepMed
Welcome to GrepMed!
Sign up
to bookmark, like, and share #FOAMed images to reach an audience of
> 1 million weekly!
Sign up
×
@natcorbo_pa
0
0
0
Contributor Ranks
Latest Searches
Uploads
Bookmarks
Likes
60
results
sorted by: time
bookmarks
views
likes
comments
diagnosis
differential
management
abdominalpain
cardiology
pharmacology
antibiotics
causes
comparison
infectiousdisease
mnemonic
table
bacteria
coverage
covid
covid19
heart
infectiousdiseases
physicalexam
vindicate
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant schizophrenia. It has a greater effect on negative symptoms and in patients with suicidal ideation than other antipsychotic drugs. Clozapine Pharmacokinetics - Absorption – Well absorbed with an oral bioavailability of 50% following first-pass metabolism - Distribution – Highly variable volume of distribution (1.6 – 7 L/kg). - Metabolism - Clozapine is extensively metabolized in the liver by CYP1A2 (major), CYP2D6 and CYP3A4. Most metabolites are inactive, although one (N-desmethylclozapine) has some limited activity at dopamine receptors. - Elimination – elimination half-life of 12-14 hours, with a mix of renal (50%) and fecal (30%) elimination routes for metabolites. Clozapine is associated with common adverse effects, such as: - hypersalivation - urinary incontinence - constipation - sedation. - cholinergic rebound upon its cessation (should be tapered off if possible) Clozapine is known to cause rare but serious adverse effects including: - severe neutropenia - seizures - myocarditis - increased mortality in elderly patients with dementia-related psychosis - increased risk of orthostatic hypotension, bradycardia, and syncope By Dr. Kathryn Watson @Kat_Watson #Clozapine #Toxicology #Toxicity #Diagnosis #Pharmacology
Newborn Infant - Routine Examination Birthweight, gestational age and birthweight percentile are noted. General observation Of the baby's appearance, posture and movements provides valuable information about many abnormalities. The baby must be fully undressed during the examination. The head circumference is measured with a paper tape measure and its centile noted. This is a surrogate measure of brain size. The fontanelle and sutures are palpated. The fontanelle size is very variable. The sagittal suture is often separated and the coronal sutures may be overriding. A tense fontanelle when the baby is not crying may be due to raised intracranial pressure and cranial ultrasound should be performed to check for hydrocephalus. A tense fontanelle is also a late sign of meningitis. The face is observed. If abnormal, this may represent a syndrome, particularly if other anomalies are present. Down syndrome is the most common, but there are hundreds of syndromes. When the diagnosis is uncertain, a book or a computer database may be consulted and advice should be sought from a senior paediatrician or geneticist. If plethoric or pale, the haematocrit should be checked to identify polycythaemia or anaemia. Central cyanosis, which always needs urgent assessment, is best seen on the tongue. Jaundice within 24 h of birth requires further evaluation. The eyes are checked for red reflex with an ophthalmoscope. If absent, may be from cataracts, retinoblastoma and corneal opacity. This reflex is not present in infants with pigmented skin, but the retinal vessels can be visualised. The palate needs to be inspected, including posteriorly to exclude a posterior cleft palate, and palpated to detect an indentation of the posterior palate from a submucous cleft. Breathing and chest wall movement are observed for signs of respiratory distress. On auscultating the heart, the normal rate is 110-160 beats/min in term babies, but may drop to 85 beats/min during sleep. On palpating the abdomen, the liver normally extends 1—2 cm below the costal margin, the spleen tip may be palpable, as may the kidney on the left side. Any intra-abdominal masses, which are usually renal in origin, need further investigation. The femoral pulses are palpated. Their pulse pressure is: - reduced in coarctation of the aorta. This can be confirmed by measuring the blood pressure in the arms and legs - increased if there is a patent ductus arteriosus. The genitalia and anus are inspected on removing the nappy. Patency of the anus is confirmed. In boys, the presence of testes in the scrotum is checked by palpation. Muscle tone is assessed by observing limb movements. Most babies will support their head briefly when the trunk is held vertically. The whole of the back and spine is observed, looking for any midline defects of the skin. The hips are checked for developmental dysplasia of the hips (DDH). This is left until last as the procedure is uncomfortable. #Newborn #Infant #PhysicalExam #Examination #Peds #Pediatrics #Diagnosis
Novel Antibiotics Against Resistant Gram-negative Bacteria - IDagram @ID_agram #Novel #Antibiotics #Resistant #GramNegative #Bacteria #Management #Resistance
Idagram of novel antibiotics for Resistant Gram Positive Bbacteria Ceftaroline (IV), Ceftobiprole (IV), lclaprim (IV), Delafloxacin (PO,IV), Dalbavancin (IV x 1 dose or IV x 2 one wk apart), Oritavancin (IV x 1 dose), Tedizolid (PO, IV), Omadacycline (PO, IV) - IDagram @ID_agram #Antibiotics #Resistant #GramPositive #Bacteria #Management #Novel #Resistance
Intern Pocket Cards - Antibiogram and Susceptibilities VRE - MRSA - GRAM POSITIVES - GRAM NEGATIVES - PSEUDOMONAS - ANAEROBES - ATYPICALS - ANAEROBES - ATYPICALS - penicillin, amoxicillin/ampicillin, amox-clav/amp-sulbactam, methicillin/oxacillin, piperacilin-tazobactam/ticarcillin-clavulanate - 1st gen cephalosporins, 2nd gen cephalosporins (cefoxitin,cefotetan), 3rd gen cephalosporins, 4th gen cephalosporins (cefepime), (ceftazidime), 5th gen cephalosporins (ceftaroline) - carbapenems, aztreonam - ceftaz-avi, ceftolozane-tazo, mero-vabor / imi-relee, cefiderocol - TMP-SMX - clindamycin - vancomycin / oritavancin / dalbavancin - daptomycin, linezolid / tedizolid - tetracyclines (doxycycline) - tigecycline / eravacycline / omadacycline - lefamulin - macrolides - quinolones (delafloxacin, moxifloxacin) - aminoglycosides - fosfomycin - colistin / polymyxin B - metronidazole Antimicrobial Stewardship: → What syndrome? (e.g., UTI, bacteremia, etc.) What bug? (Use culture data. If none, what is most likely?) → What drug? (IV or PO?) Check local antibiogram. Initial duration of therapy? → Can I de-escalate? If on IV, can I switch to PO? Can I stop? (Use clinical data like vitals, WBC count and cultures to tailor therapy) → Discharge patient - Confirm type of IV access (if indicated) and if frequency of medication and lab is feasible at discharge destination by Jennifer Fulcher, MD, PhD @FulchJen Full Inpatient Pocket Cards Collection: https://bit.ly/pocketcardset #Antibiogram #Susceptibilities #antibiotics #management #pharmacology
Antibiotics - Spectrum and Coverage Antibiogram #Antibiogram #Antibiotics #Classes #Bacterial #Spectrum #Coverage #Susceptibility #Susceptibilities #InfectiousDiseases #Pharmacology
Reference Laboratory Values - Fishbone Shorthand Complete Blood Count (CBC), Basic Metabolic Panel (BMP), Liver Function Tests (LFTs) and Arterial Blood Gas (ABG) #Laboratory #Values #Labs #Reference #Normal #Fishbone #Shorthand
Summary table of heart murmurs associated with mitral and aortic valve diseases as well as their signs and symptoms. Visit gramproject.com for more medical diagrams, tables and flowcharts for use in your learning, revision and teaching. #diagnosis #heart #cardiology #comparison
Heart Murmurs - Classification - Adults Dr. André Mansoor @AndreMansoor - Frameworks for Internal Medicine https://amzn.to/2LmUODZ #Heart #Murmurs #Systolic #Diastolic #Classification #Adult #Cardiology #Differential #Diagnosis
Heart Sounds #Heart Murmurs #Heart Sounds #Algorithm #Heart #Murmurs #cardiology #diagnosis #differential
empty