Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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management diagnosis lysis oncology potassium syndrome tumor associated differential emergencies endocrinology hematology hemeonc hypokalemia leukostasis low nephrology oncologic polymorphic tdp
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
chemosensitive malignancy ... ) occur in high ... 6L/day) • For hyperkalemia ... otherwise treat with "hyperkalemia ... Lysis #Syndrome #TLS
Treatment algorithm for malignancy-associated hypercalcemia. Hypercalcemia - Renal Failure → Dialysis with low Ca++ bath Aggressive IV hydration
Treatment algorithm ... hypercalcemia. ... Hypercalcemia - ... #associated #hypercalcemia ... #Treatment #algorithm
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... Algorithm Before ... evaluating hypokalemia ... urinary losses: • High ... ↑ Aldosterone: Malignant
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Hyperkalemia Management ... the cause & optimize ... leadingto hyperkalemia ... / Removal #Hyperkalemia ... #high
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... WBC count cause ... leukapheresis - TLS ... Spontaneous if high ... hydration - Hyperkalemia
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... Treat underlying cause ... plasmapheresis Hypercalcemia ... of malignancy:
Recurrent Polymorphic VT/Torsades de Pointes - Management Algorithm Drugs that prolong QT interval: • Class 1a (quinidine,
, sotalol) • Propofol ... Hypomagnesemia • Hypokalemia ... • Hypocalcemia ... (rarely) Treatment ... 1b (lidocaine)- case
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