Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Antibiotics as Antidotes ... Valproic Acid Toxicity ... #Antibiotics #Antidotes ... #Toxicology #Pharmacology
Electrocardiographic Features of Digoxin Toxicity
 β€’ Virtually any arrhythmia is possible. None specific for digoxin toxicity
Toxicity β€’ Virtually ... None specific for digoxin ... toxicity β€’ Classic ... Electrocardiogram #ekg #ecg #toxicology ... #cardiology #diagnosis
Almost any type of cardiac arrhythmia is seen in digitalis toxicΒ­ity. However, type II second-degree atrioventricular
seen in digitalis toxicΒ­ity ... changes in digitalis toxicity ... #Diagnosis #Cardiology ... #EKG #ECG #Digoxin ... #Toxicity #Toxicology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... toxicity. ... toxicity isn't ... #Pharmacology # ... Pathophysiology #cardiology
Digoxin Pharmacology and Monitoring

 β€’ Digoxin’s half-life is 30-45 hours in healthy adults
 β€’ When monitoring
Digoxin Pharmacology ... Monitoring β€’ Digoxin ... #Pharmacology # ... Monitoring #toxicology ... #management #toxicity
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
at anytime if toxicity ... post dose (C2) Digoxin ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Clinically Significant Cardiovascular Drug-Drug Interactions With OTC Supplements and Herbal Products
Angiotensin-Converting Enzyme Inhibitors (ACEIs)
 β€’ Night-blooming
and tachycardia Digoxin ... toxicity β€’ Danshen ... increasing risk for toxicity ... supplementals #herbal #pharmacology ... #DDI #table #cardiology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... evidence of marrow toxicity ... Methotrexate #Leucovorin #Antidote ... #Toxicology #Toxicity ... #Management #Pharmacology