Mithu Maheswaranathan, MD @MithuRheum
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Rheumatologist at Duke University Creator of Rheum OnePagers ➡ RheumOnePagers.com Twitter: @MithuRheum ➡ https://twitter.com/MithuRheum
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diagnosis rheumatology antibodies differential ana antinuclear table associations autoantibodies clinical crisis management mimics msas myositis nephrology renal sclerosis signs specific
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... (SSc) • Nucleolar ... systemic sclerosis/scleroderma ... systemic sclerosis/scleroderma ... Antibodies #ANA #patterns
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
serial dilution, a pattern ... significant • Pattern ... : The ANA patterns ... not specific ANA Patterns ... (SSc) • Nucleolar
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis (Scleroderma ... 3 Subtypes of Scleroderma ... (SSc): • Limited ... renal crisis (SRC ... #SSc #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Anti-JO-1, Others: SRP ... TIF1y, MDA5 • Scleroderma ... Systemic Sclerosis, SSc
Scleroderma Mimics • Scleredema • Scleromyxedema (papular mucinosis) • Eosinophilic Fasciitis • Nephrogenic Systemic Fibrosis •
Scleroderma Mimics ... • Scleredema ... @MithuRheum #Scleroderma
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Scleroderma Renal ... Crisis (SRC) ... Presentation of Scleroderma ... MithuRheum #SRC ... #Scleroderma #Renal
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
(IMNM): HMGCR, SRP
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