Mithu Maheswaranathan, MD @MithuRheum
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Rheumatologist at Duke University Creator of Rheum OnePagers ➡ RheumOnePagers.com Twitter: @MithuRheum ➡ https://twitter.com/MithuRheum
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diagnosis rheumatology ana antibodies antinuclear associations autoantibodies mimics sclerosis signs ssc symptoms table workup
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
(Scleroderma) ... (SSc): • Limited ... renal crisis (SRC ... #SSc #rheumatology ... signs #symptoms #testing
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... (SSc) • Nucleolar ... sclerosis/scleroderma ... Antibodies #ANA #patterns ... rheumatology #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
serial dilution, a pattern ... significant • Pattern ... : The ANA patterns ... (SSc) • Nucleolar ... rheumatology #diagnosis #differential
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Anti-JO-1, Others: SRP ... TIF1y, MDA5 • Scleroderma ... (Systemic Sclerosis ... , SSc): Anti-centromere
Scleroderma Mimics • Scleredema • Scleromyxedema (papular mucinosis) • Eosinophilic Fasciitis • Nephrogenic Systemic Fibrosis •
Scleroderma Mimics ... • Scleredema ... • Nephrogenic Systemic ... @MithuRheum #Scleroderma ... #rheumatology #differential
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