The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Mixed Urinary Incontinence ... tumour, stone, BPH ... Incr PVR if a complication ... #Mixed #Pathophysiology ... #Signs #Symptoms
Complications of Measles: Pathogenesis and Clinical Findings
 • ADEM -> Fever, headache, neck stiffness, BBD, mental
Complications of ... neck stiffness, BBD ... infections #Measles #Complications ... diagnosis #signs #symptoms ... #pathophysiology
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
chromosome 21) Signs / Symptoms ... / Complications ... primitive reflexes, incontinence ... AlzheimersDisease #Dementia #pathophysiology ... diagnosis #signs #symptoms
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
spine Signs / Symptoms ... / Complications ... retention -> Overflow Incontinence ... Syndrome #MSK #pathophysiology ... #diagnosis #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... /Complications: ... • Gonadal hypoplasia ... Syndrome #genetics #pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
Benign Prostatic Hyperplasia ... Urgency, nocturia, incontinence ... bladder stones #BPH ... Benign #Prostatic #Hyperplasia ... #Prostate #Pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Medications
Aging
 -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic Hyperplasia ... cell nuclei -> Hyperplasia ... inflammation #BPH ... #Prostate #Pathophysiology ... #Medications #Pharmacology
Benzodiazepine (BZD) withdrawal: clinical findings and complications

 • Activation of ACC and OFC -> Feelings of
Benzodiazepine (BZD ... clinical findings and complications ... #withdrawal #pharmacology ... #pathophysiology ... diagnosis #signs #symptoms
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
congenital adrenal hyperplasia ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Findings Diagnostic Criteria ... feet Signs/Symptoms ... /Complications: ... #Diagnosis #Pathophysiology ... #Signs #Symptoms