The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms pharmacology sideeffects allergic definitions hypersensitivity inhibitors reactions serotonin types anticonvulsants aseptic bulimianervosa caudaequina cecs chronicexertional compartmentsyndrome complications
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Stevens-Johnson Syndrome ... #Types #Classification ... #Diagnosis #Definitions
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
• Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Dizziness - Nausea ... #SideEffects #Psychiatry ... #Diagnosis #Signs
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... Vomiting Serotonin Syndrome ... gain Incr NE: Nausea ... #SideEffects #Psychiatry ... #Diagnosis #Signs
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... Stevens-Johnson Syndrome ... Systemic effect -> Nausea ... Pathophysiology #Psychiatry
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
leading to an allergic ... cell surfaces causes ... causes development ... #Types #Classification ... #Diagnosis #Definitions
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... #CaudaEquina #Syndrome ... #MSK #pathophysiology ... #diagnosis #symptoms
Mental Status Exam (MSE) Note: The MSE is a "snapshot" of a patient at a specific time. You
Mental Status Exam (MSE ... ) Note: The MSE ... , the symptoms caused ... MentalStatusExam #MSE ... #psychiatry #diagnosis
Chronic Exertional Compartment Syndrome (CECS) • Diagnosis Of CECS requires patient to undergo the same exertional
Exertional Compartment Syndrome ... (CECS) • Diagnosis ... activity that causes ... • Diagnostic ... signs #symptoms #msk
Serotonin Syndrome: Pathogenesis and Clinical Findings Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and
Serotonin Syndrome ... ingestion and most cases ... make a clinical diagnosis ... Pathophysiology #Psychiatry ... #Diagnosis #Signs
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
• Boerhaave syndrome ... hormone levels cause ... pathophysiology #diagnosis ... signs #symptoms #psychiatry
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