The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... Signs/Symptoms/Complications ... pathophysiology #endocrinology ... #diabetes
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... /Symptoms/Complications ... Obesity -> Type 2 diabetes
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Signs / Symptoms ... / Complications ... Hyperprolactinemia • Diabetes ... #SideEffects #endocrinology
Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings

Predisposing Factors:
 - Immunocompromised, Diabetes,
 - Elderly, Female
Immunocompromised, Diabetes ... lower tract: As a complication ... Pathophysiology #Signs
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
Bulimia Nervosa: Signs ... Symptoms related to complications ... frequent urination (diabetes ... weight Russell's Sign ... #symptoms #psychiatry
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
cystitis, UTI), diabetes ... Incr PVR if a complication ... Pathophysiology #Signs
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
Anorexia Nervosa: Complications ... Death - Cardiac complications ... mortality rates of all psychiatric ... pathophysiology #diagnosis #signs ... #symptoms #psychiatry
Bulimia Nervosa: Complications
GASTROINTESTINAL
 • Dehydration & inability to digest food -> Constipation
 • Recurrent vomiting exposes
Bulimia Nervosa: Complications ... BulimiaNervosa #Complications ... pathophysiology #diagnosis #signs ... #symptoms #psychiatry