The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms/Complications ... Obesity -> Type 2 diabetes ... PraderWilli #Syndrome #genetics ... #pathophysiology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology ... #diabetes
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Boutonniere Deformity: Pathogenesis and Complications
 • Hyperextension of DIP
 • Flexion of PIP
=> Boutonniere Deformity =>
Pathogenesis and Complications ... joint => Premanent contracture ... Boutonniere #Deformity #pathophysiology ... #msk #rheumatoidarthritis
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Signs / Symptoms / Complications ... Hyperprolactinemia • Diabetes ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Dupuytren’s Disease: Pathogenesis and Clinical Findings
 • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia
smoking and/or diabetes ... Dupuytrens #Disease #Contractures ... #pathophysiology ... #msk