The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipid • GH excess ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... theca cells • Ovulation ... #OvarianCycle #pathophysiology ... #menstruation #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... share the same pathophysiology ... fraction • HTN #GrowthHormone ... signs #symptoms #endocrinology ... #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... production by the pituitary ... Hyperthyroidism #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
Ovarian Cycle – Ovulation ... on the anterior pituitary ... #OvarianCycle #pathophysiology ... #Ovulation #endocrinology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
Ovulation • ... on the anterior pituitary ... #UterineCycle #MenstrualCycle ... #OvarianCycle #pathophysiology ... #comparison #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained
Early Follicular Phase (Days 0-5)
 • Granulosa cells
production by pituitary ... back on anterior pituitary ... preparing for ovulation ... #OvarianCycle #pathophysiology ... FollicularPhase #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained
 • The LH surge can be thought
slide) Besides ovulation ... hypothalamus and anterior pituitary ... #OvarianCycle #pathophysiology ... #LutealPhase #endocrinology