The Calgary Guide to Understanding Disease @TheCalgaryGuide
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menstrualcycle ovariancycle diagnosis gh symptoms comparison feedbackloop follicularphase glftap hyperthyroidism lutealphase macroadenoma masseffects menstruation mnemonic overproduction primary ra rheumatoidarthritis sideeffects
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... fraction • HTN #GrowthHormone ... #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... theca cells • Ovulation ... #OvarianCycle #pathophysiology ... #menstruation #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained Around Day 14, estrogen exerts sudden +++ positive feedback
Ovarian Cycle – Ovulation ... on the anterior pituitary ... #OvarianCycle #pathophysiology ... #Ovulation #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles Note: Some charts show different relative levels of
Ovulation • ... on the anterior pituitary ... #UterineCycle #MenstrualCycle ... #OvarianCycle #pathophysiology ... #comparison #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
production by pituitary ... back on anterior pituitary ... preparing for ovulation ... #OvarianCycle #pathophysiology ... FollicularPhase #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained • The LH surge can be thought
slide) Besides ovulation ... hypothalamus and anterior pituitary ... #OvarianCycle #pathophysiology ... #LutealPhase #endocrinology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
affects 1% of population ... joint capsule exceeds ... Extra-articular signs ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
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