The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis msk acute caudaequina feedbackloop gh glftap growthhormone hyperthyroidism injury macroadenoma masseffects mnemonic neurology orthopedics psychiatry riskfactors sideeffects spinalcord
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... production by the pituitary ... Signs/Symptoms: ... Pretibial myxedema #Primary ... Hyperthyroidism #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
lumbar spine Signs ... / Symptoms / Complications ... reflexes) • Urinary ... bladder/bowel dysfunction ... #signs
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Bladder retention -> Primarily ... Upper Extremity Dysfunction ... hemicord lesion -> Primarily ... pathophysiology #signs ... #symptoms #msk
Anorexia Nervosa: Pathogenesis and Risk Factors Biological Risk Factors • Gender: F > M • Genetics: concordance
abuse, familial dysfunction ... athletics) #AnorexiaNervosa ... pathophysiology #diagnosis #signs ... #symptoms #psychiatry
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