The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... lipolysis Signs/Symptoms ... lipid • GH excess ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... fraction • HTN #GrowthHormone ... diagnosis #signs #symptoms ... #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
sudden +++ positive feedback ... negative to positive feedback ... MenstrualCycle #OvarianCycle ... pathophysiology #Ovulation #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Narcissistic Personality Disorder: Pathogenesis and Clinical Findings
 • Arrogant, Haughty Behaviors or Attitude - Often display
only by constant feedback ... - Entitlement, Excess ... Criteria #Signs #Symptoms