The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipid • GH excess ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... fraction • HTN #GrowthHormone ... #diagnosis #signs ... #symptoms #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... LH release from pituitary ... MenstrualCycle #OvarianCycle ... #menstruation #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... production by the pituitary ... Hyperthyroidism #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
on the anterior pituitary ... MenstrualCycle #OvarianCycle ... pathophysiology #Ovulation #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained
Early Follicular Phase (Days 0-5)
 • Granulosa cells
production by pituitary ... back on anterior pituitary ... production by pituitary ... MenstrualCycle #OvarianCycle ... FollicularPhase #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained
 • The LH surge can be thought
hypothalamus and anterior pituitary ... MenstrualCycle #OvarianCycle ... #LutealPhase #endocrinology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
on the anterior pituitary ... MenstrualCycle #OvarianCycle ... pathophysiology #comparison #endocrinology