The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
TypeIII #Type3 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
TypeIV #Type4 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
cells recruited Complications ... #TypeI #Type1 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
#Type2 #Type2 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Signs / Symptoms / Complications ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Major Depressive Disorder: Complications
 • Recurrent Depressive Episodes
 • Early parenthood
 • Social isolation and interpersonal
Depressive Disorder: Complications ... MajorDepressiveDisorder #Complications ... #Pathophysiology ... #Psychiatry
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
Anorexia Nervosa: Complications ... Death - Cardiac complications ... mortality rates of all psychiatric ... #pathophysiology ... signs #symptoms #psychiatry