The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis symptoms 21hydroxylasedeficiency 21ohd alzheimersdisease caudaequina dementia diabetes diabeticketoacidosis dka genetics geriatrics glftap macroadenoma masseffects mnemonic msk pagetsdisease pediatrics
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs ... / Symptoms / Complications ... Executive planning dysfunction ... concentration • Motor dysfunction ... geriatrics #diagnosis #signs
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
lumbar spine Signs ... / Symptoms / Complications ... bladder/bowel dysfunction ... diagnosis #symptoms #signs
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Signs / Symptoms ... / Complications ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Signs/Symptoms/Complications ... pathophysiology #endocrinology
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... causes middle ear dysfunction ... pathophysiology #diagnosis #signs ... #symptoms #complications
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