The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... Angioedema #Anaphylaxis ... #pathophysiology ... #immunology #diagnosis
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
X-Linked Agammaglobulinemia ... 40% of patients diagnosed ... common antigens #Agammaglobulinemia ... #XLinked #pathophysiology ... #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
T-Cell activation takes ... cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... shoulder joint inflammation ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #staging #msk
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... mucosa leads to inflammation ... are connected) Stage ... #Mastoiditis #pathophysiology ... signs #symptoms #diagnosis
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
altered mental status ... • Inflammation ... C5C9Deficiency #Complement #pathophysiology ... #immunology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
hypercoagulable state ... Hypercoagulable state ... viscosity and inflammation ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... mild synovial inflammation ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis ... #pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... UTIs & bladder stones ... Hyperplasia #Prostate #Pathophysiology ... Signs #Symptoms #Diagnosis
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Inflammatory Stage ... site Soft Callus Stage ... #Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors