The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... audible Lungs: • Inflammation ... on CXR • RA inflammation ... symptoms #diagnosis #ExtraArticular
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology
Periorbital Cellulitis: Pathogenesis and Clinical Findings
Definitions:
a. Dacryoadenitis: infection of the lacrimal glands
b. Conjunctivitis: inflammation of the
Conjunctivitis: inflammation ... Chalazion: a benign ... localized infection or inflammation
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
Inflammation ... pathophysiology #immunology
Benign Prostatic Hyperplasia: Pathogenesis and Medications
Aging
 -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic ... Decreased Prostatic inflammation ... #BPH #Benign
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
Benign Prostatic ... FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... stones #BPH #Benign
Ankylosing Spondylitis: Extra-articular Manifestations
 • Ocular - Inflammation of the iris, the anterior part of the
Manifestations • Ocular - Inflammation ... • Cardiac - Inflammation ... - Ligamentous inflammation ... Respiratory (rare) - Inflammation ... AnkylosingSpondylitis #Extraarticular