The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms ophthalmology pediatrics allergy ankylosingspondylitis c5c9deficiency cascade childhood complement complications hypersensitivityreaction immunization inflammatory manifestations orbital otitismedia periorbital ra
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... #pathophysiology ... #immunology
Orbital Cellulitis: Pathogenesis and Clinical Findings Definitions: a. Chemosis: Edema of the bulbar conjunctiva b. Panopthalmitis: inflammation of all
Orbital Cellulitis ... Panopthalmitis: inflammation ... Endopthalmitis: inflammation ... Blindness #Orbital #Cellulitis ... #pathophysiology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... on CXR • RA inflammation ... RheumatoidArthritis #RA #pathophysiology ... symptoms #diagnosis #ExtraArticular
Periorbital Cellulitis: Pathogenesis and Clinical Findings Definitions: a. Dacryoadenitis: infection of the lacrimal glands b. Conjunctivitis: inflammation of the
Periorbital Cellulitis ... Conjunctivitis: inflammation ... localized infection or inflammation ... #Periorbital #Cellulitis ... #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
• Inflammation ... C5C9Deficiency #Complement #pathophysiology ... #immunology
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... #OtitisMedia #pathophysiology ... symptoms #signs #peds
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Diphtheria Toxin -> URT inflammation ... encephalitis and cellulitis ... Metabolites -> Inflammation ... #Immunization #peds ... #pediatrics #pathophysiology
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Manifestations • Ocular - Inflammation ... • Cardiac - Inflammation ... - Ligamentous inflammation ... AnkylosingSpondylitis #Extraarticular ... Complications #pathophysiology
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