The Calgary Guide to Understanding Disease @TheCalgaryGuide
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hypersensitivityreaction diagnosis signs symptoms anaphylaxis bph pharmacology prostate prostatic urology anticonvulsants c5c9deficiency cascade cellulitis complement inflammatory management mechanism medications moodstabilizers
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... Initial exposure to allergen ... cells or CTLs -> Inflammation ... #Immunology #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen ... #Immunology #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... #pathophysiology ... #immunology
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic ... Hyperplasia: Pathogenesis ... Decreased Prostatic inflammation ... #BPH #Benign ... #Prostate #Pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
exposure to a likely allergen ... exposure to known allergen ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic ... Hyperplasia: Pathogenesis ... stones #BPH #Benign ... #Prostatic #Hyperplasia ... #Prostate #Pathophysiology
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
provided, as well as allergy ... Treatments #Management #pathophysiology ... #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... reaction -> Benign ... #SideEffects #Pathophysiology
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