The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... with keratotic scaling ... that extend inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... : -> Shooting, stabbing ... pain Lasegue's sign ... Radiculopathy #MSK ... #diagnosis #signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
as post-inflammatory ... pathophysiology #diagnosis ... #symptoms #signs ... #stages #staging ... #msk
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... mild synovial inflammation ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
sensory • Before diagnosis ... , Stabbing) - ... MeralgiaParesthetica #MSK ... #differential #diagnosis ... #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... : Extension of inflammatory ... pathophysiology #signs ... #symptoms #diagnosis
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
lumbar spine Signs ... pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis ... #symptoms #signs
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... Extra-articular signs ... pathophysiology #signs ... #symptoms #diagnosis
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... ophthalmology #diagnosis ... #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
alterations (result of aging ... FGF-related proteins) Inflammation ... activation of inflammatory ... Pathophysiology #Urology #Signs ... #Symptoms #Diagnosis