The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms hypersensitivityreaction staging adhesivecapsulitis benign bph c5c9deficiency centralretinalartery comparison complement complications crao degenerative disruptors fracture frozenshoulder healing hyperplasia
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... T-Cell activation takes ... cells or CTLs -> Inflammation ... #Immunology #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... release the pro-inflammatory ... secretion • Inflammatory ... #Immunology #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... FrozenShoulder #pathophysiology ... #staging #msk
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
the complement cascade ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... mucosa leads to inflammation ... are connected) Stage ... : Extension of inflammatory ... #Mastoiditis #pathophysiology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... Swollen Joints • Inflammation ... mild synovial inflammation ... Comparison #Versus #MSK ... JointPain #Diagnosis #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
-> Complement cascade ... altered mental status ... • Inflammation ... C5C9Deficiency #Complement #pathophysiology ... #immunology
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacterial toxins and inflammation ... in a systemic inflammatory ... urine -> Struvite stones ... UrinaryTractInfection #LUTI #Pathophysiology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... hypercoagulable state ... Hypercoagulable state ... viscosity and inflammation ... Occlusion #CRAO #pathophysiology
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