The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... pathophysiology #diagnosis ... #symptoms #signs ... #msk
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... are connected) Stage ... : Extension of inflammatory ... pathophysiology #signs #symptoms ... #diagnosis #otology
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... Swollen Joints • Inflammation ... mild synovial inflammation ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
-> Complement cascade ... altered mental status ... • Inflammation ... pathophysiology #immunology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... hypercoagulable state ... viscosity and inflammation ... ophthalmology #diagnosis ... #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... UTIs & bladder stones ... #Diagnosis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... pathophysiology #signs #symptoms ... #diagnosis
Mental Status Exam (MSE)
Note: The MSE is a "snapshot" of a patient at a specific time.
You
Mental Status Exam ... (MSE) Note: The ... clothing, appears stated ... of illness, the symptoms ... #psychiatry #diagnosis