The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs stages symptoms adhesivecapsulitis allergy comparison complications degenerative disruptors frozenshoulder jointdisease jointpain lupus manifestations mucocutaneous orthopedics sle type1
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
, humeral head fracture ... healing (i.e. local ... tissue healing ... signs #stages #staging ... #msk
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
degranulation, leading ... release the pro-inflammatory ... secretion • Inflammatory ... #TypeI #Type1 #HypersensitivityReaction ... #Allergy #Immunology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... exposed areas -> Scaring ... with keratotic scaling ... that extend inflammation ... -> Incr local inflammation
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Swollen Joints • Inflammation ... forces that are wearing ... mild synovial inflammation ... Larger, weight-bearing ... Comparison #Versus #MSK
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing ... this process) Inflammatory ... #Fracture #Healing ... #Orthopedics #msk ... #Staging #pathophysiology
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