The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs complications manifestations otitismedia pediatrics acute adhesivecapsulitis ankylosingspondylitis benign bph cascade centralretinalartery childhood cholesteatoma crao extraarticular frozenshoulder hyperplasia
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Mastoiditis: Pathogenesis ... mucosa leads to inflammation ... : Extension of inflammatory ... abscesses #Mastoiditis ... pathophysiology #signs #symptoms
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... hearing loss, mastoiditis ... pathophysiology #diagnosis #symptoms ... #signs #peds #pediatrics
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Infection and inflammation ... severe Signs/Symptoms ... sensorineural is rare • Mastoiditis ... pathophysiology #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... diagnosis #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... stop, but post-inflammatory ... pathophysiology #diagnosis #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... diagnosis #signs #symptoms
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Diphtheria Toxin -> URT inflammation ... hemorrhagic rash; symptoms ... Metabolites -> Inflammation ... non-specific viral symptoms ... #Immunization #peds
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... pathophysiology #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... emptying - Voiding Symptoms ... Urology #Signs #Symptoms
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