The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology agammaglobulinemia allergy c5c9deficiency cascade diagnosis gonorrhea henochscholeinpurpura hsp humoral hypersensitivityreaction immunity inflammation inflammatory oncogenesis oncology primarycare signs stds stis
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections ... Oncogenesis Note: A retrovirus ... Examples of retrovirus-associated ... /leukemia) #Retroviral ... pathophysiology #immunology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... (GD-IgA1). ... -> Decr IgA serum ... -> adhesion of IgA ... Activation of complement
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... pathophysiology #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
autoimmune antibodies (IgG ... , rarely IgM) against ... activates the complement ... HypersensitivityReaction #Allergy #Immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... C7, C8, C9 -> Complement ... pathophysiology #immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
undetectable levels of IgA ... , IgG, and IgM ... pathophysiology #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... - Activate Complement ... : Abs activate complement ... pathophysiology #immunology
Gonorrhea: Pathophysiology - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
activation of complement ... - Secretion of IgA
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