The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
a stroke that caused ... post-inflammatory healing ... scapulothoracic) #AdhesiveCapsulitis ... FrozenShoulder #pathophysiology ... #staging #msk
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Tetanus Toxin -> Spores ... sensorineural hearing ... lymph -> Koplik's spots ... Congenital anomalies: hearing ... peds #pediatrics #pathophysiology
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
ligament substance leading ... ligament substance leading ... LowAnkleSprain #Sports ... #MSK #orthopedics ... Grades #Diagnosis #pathophysiology
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Hypertension Stage ... -> AV nicking Stage ... -> Cotton-wool Spots ... -> Elschnig's Spots ... #Retinopathy #pathophysiology
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
other proteins leaking ... -> Cotton-wool spots ... ischemia -> Venous beading ... retinal ischemia causes ... complications #pathophysiology
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... Larger, weight-bearing ... > Stiffness is short-lived ... Comparison #Versus #MSK ... JointPain #Diagnosis #pathophysiology
RICE: Mechanism of Action
Rest (weight bearing or stressful motion discontinued)
Ice (applied to injury)
Compression (wrap applied to
Rest (weight bearing ... heart) #RICE #Sports ... #pathophysiology ... #mechanism #MSK
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... are connected) Stage ... labyrinth): Tinnitus, hearing ... loss, nausea, vomiting ... #Mastoiditis #pathophysiology
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Inflammatory Stage ... site Soft Callus Stage ... Fluoroquinolones - Causes ... #msk #Staging # ... pathophysiology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
hypercoagulable state ... Hypercoagulable state ... -> Cherry-red spot ... retinal edema caused ... Occlusion #CRAO #pathophysiology