The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms psychiatry complications orthopedics immunology syndrome endocrinology differential ophthalmology behavioraldisorder hypersensitivityreaction sideeffects sports classification diabetes fractures injury pharmacology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... causes development ... of allergen-specific ... Allergic reaction ... #Immunology #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen ... #Immunology #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... antigens are the cause ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... Tissue edema #Allergic ... Rhinitis #Rhinorrhea #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology
Spondylosis - Pathogenesis and Complications Vertebral disease that may compress the vertebral canal from all sides Note: Do
#Spondylosis #pathophysiology ... #msk #complications
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
within GI and URT causes ... Maternal viremia causes ... Hematogenous spread causes ... evasion techniques cause ... peds #pediatrics #pathophysiology
Subjective Tinnitus: Pathogenesis and clinical findings Subjective Tinnitus - Perceived sound with no acoustic stimulus, heard only
refers to sound caused ... #Tinnitus #Causes ... #pathophysiology
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
StressFractures #msk ... #orthopedics #pathophysiology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Femur #Fractures #msk ... #differential #causes ... #pathophysiology
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