The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... Accumulated micro-damage exceeds ... #StressFractures ... #msk #orthopedics ... pathophysiology #symptoms #signs
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... the etiology Signs ... pathophysiology #endocin ... #endocrinology ... #symptoms #signs
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... Acne • Coarse features ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
thrombocytopenia ENDOCRINE ... increased risk of fracture ... - Lethargy or Excess ... highest mortality rates ... pathophysiology #diagnosis #signs