The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis complications signs stages symptoms adhesivecapsulitis caudaequina contractures diabetic diabeticfoot diabeticketoacidosis discherniations disease disruptors dka dupuytrens fracture frozenshoulder glftap
Diabetic Retinopathy: Pathogenesis and clinical findings Mild Non-proliferative DR • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... ischemia -> Venous beading ... retinal ischemia causes ... Neovascularization #Diabetic ... #Retinopathy #Diabetes
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... out of cells may cause ... Abdominal pain, nausea ... pathophysiology #endocrinology ... #diabetes
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... Glycosylation - AGE cause ... neuropathy => Diabetic ... a person with diabetes ... in inopportune loading
Disc Herniations - Pathogenesis and Complications • 90% of Lumbar disc herniations happen at L4/5 and L5/S1 •
happen at C6/7 Aging ... -> Mechanical loading ... complications #msk
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
autoimmune disorders (diabetes ... a stroke that caused ... signs #stages #staging ... #msk
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
For pituitary masses ... Hyperprolactinemia • Diabetes ... Headaches • Nausea ... #SideEffects #endocrinology
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK
Dupuytren’s Disease: Pathogenesis and Clinical Findings • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia
Clinical Findings • Aging ... smoking and/or diabetes ... pathophysiology #msk
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fluoroquinolones - Causes ... #Orthopedics #msk ... #Staging #pathophysiology
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