The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... -> Cotton-wool spots ... retinal ischemia causes ... Neovascularization #Diabetic ... #Retinopathy #Diabetes
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Chronic Hypertensive Retinopathy ... Hypertension Stage ... -> Cotton-wool Spots ... -> Elschnig's Spots ... #Hypertensive #Retinopathy
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
autoimmune disorders (diabetes ... a stroke that caused ... side) Second Stage ... movement) Third Stage ... #staging #msk
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings

- Predisposing Factors:  Immunocompromised state, diabetes, elderly, female
Immunocompromised state ... , diabetes, elderly ... , female (short
Dupuytren’s Disease: Pathogenesis and Clinical Findings
 • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia
Clinical Findings • Aging ... smoking and/or diabetes ... pathophysiology #msk
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Inflammatory Stage ... site Soft Callus Stage ... Fluoroquinolones - Causes ... #Orthopedics #msk ... #Staging #pathophysiology
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
frequent urination (diabetes ... Russell's Sign • Sores ... , scars, calluses
Primary Open-Angle Glaucoma: Pathogenesis and Clinical Findings
 • Risk factors -> Incr IOP, Incr age, African-American
family history, diabetes ... peri-papillary RNFL imaging ... defects => End-stage