The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis msk signs symptoms immunology psychiatry classification complications fractures hypersensitivityreaction pharmacology acute allergic anaphylaxis injury sideeffects sports antipsychotics criteria
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... as potentially ... lgE Abs persist
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Immunological Target: Allergen ... Hypersensitivity #Allergy ... #Allergic #Reactions
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... allergen's surface as
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... Plasma Cells -> lgE Abs ... Tissue edema #Allergic
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Production of lgE Abs ... leading to an allergic ... leading to an allergic ... An allergic reaction ... #Allergic #Reactions
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
cell-independent Ag: Ags ... such as peptides ... Ags tagged with ... Opsonization: Abs ... Neutralization: Abs
Acute Compartment Syndrome • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
CompartmentSyndrome #ACS ... pathophysiology #orthopedics
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
HypersensitivityReaction #Allergy
Necrotizing Fasciitis: Pathogenesis and Clinical Findings #NecrotizingFasciitis #pathophysiology #orthopedics
pathophysiology #orthopedics
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
StressFractures #msk #orthopedics
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